ZINCPharmer is free pharmacophore search software for screening the purchasable subset of the ZINC database (updates occur monthly). ZINCPharmer can import LigandScout and MOE pharmacophore definitions, as well as identify pharmacophore features directly from structure.
From PDB structure
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User Guide and Forum
Video Tutorials: Defining Pharmacophores Searching and Filtering
Targeting a protein-protein interaction? Design a pharmacophore from the PPI with PocketQuery.
The ZincPharmer search technology uses the Pharmer open source pharmacophore search technology to efficiently search a large database of fixed conformers for pharmacophore matches. The search performance scales with the complexity and breadth of the pharmacophore query. Most searches take less than a minute. Please feel free to provide feedback in the forum.
Citation: If you find ZINCPharmer useful, please cite our Nucleic Acids Research paper.
This open access technology is funded through R01GM097082 and R01GM108340 from the National Institute of General Medical Sciences. The content is solely the responsibility of the authors and does not necessarily represent the official views of the National Institute of General Medical Sciences or the National Institutes of Health.